METHODS OF TARGETING APE/REF-1 TO INHIBIT HYPOXIA SIGNALING GENES

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专利权人:

Mark R. Kelley;Melissa Fishel

发明人:

Mark R. Kelley,Melissa Fishel

申请号：

US15575519

公开号：

US20180200213A1

申请日:

2016.05.05

申请国别(地区):

US

年份:

2018

代理人:

摘要：

Methods for targeting apurinic/apyrimidinic endonuclease1/redox effector factor 1 (APE1/Ref-1) are disclosed. More particularly, methods for inhibiting APE1/Ref-1 and hypoxia-mediated signaling for decreasing survival and invasion of tumor cells exposed to hypoxic conditions are disclosed.

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中国工程科技知识中心

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http://www.ckcest.cn/home/