METHODS OF TARGETING APE1/REF 1 TO INHIBIT HYPOXIA SIGNALING GENES

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专利权人:

发明人:

KELLEY MARK R,FISHEL MELISSA

申请号：

IN201717040796

公开号：

IN201717040796A

申请日:

2017.11.15

申请国别(地区):

IN

年份:

2018

代理人:

摘要：

Methods for targeting apurinic/apyrimidinic endonucleasel /redox effector factor 1 (APEl/Ref-1) are disclosed. More particularly, methods for inhibiting APEl/Ref-1 and hypoxia-mediated signaling for decreasing survival and invasion of tumor cells exposed to hypoxic conditions are disclosed.

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