Dan J. Trepanier;Mark D. Abel;Alexander Hegmans;Shin Sugiyama;Bruce W. Fenske;Daren R. Ure
发明人:
Alexander Hegmans,Bruce W. Fenske,Dan J. Trepanier,Mark D. Abel,Daren R. Ure,Shin Sugiyama
申请号：
US13994707
公开号：
US09200038B2
申请日:
2011.12.14
申请国别(地区):
US
年份:
2015
代理人:
摘要：
Analogs of cyclosporin-A are disclosed comprising modifications of the substituents as the positions of amino acids 1 and 3, according to the following Formula. The disclosed compounds include compounds having affinity for cyclophilin, including cyclophilin-A, and reduced immunosuppressivity in comparison with cyclosporin-A and analogs thereof modified solely at position 1.
