HEGMANS, Alexander,FENSKE, Bruce, W.,TREPANIER, Dan, J.,ABEL, Mark, D.,SUGIYAMA, Shin,URE, Daren R.
申请号：
EP11848865
公开号：
EP2651965A4
申请日:
2011.12.14
申请国别(地区):
EP
年份:
2017
代理人:
摘要：
Analogs of cyclosporin-A are disclosed comprising modifications of the substituents as the positions of amino acids 1 and 3, according to the following Formula. The disclosed compounds include compounds having affinity for cyclophilin, including cyclophilin-A, and reduced immunosuppressivity in comparison with cyclosporin-A and analogs thereof modified solely at position 1.
