Alexander Hegmans,Bruce W. Fenske,Dan J. Trepanier,Mark D. Abel,Daren R. Ure,Shin Sugiyama
申请号：
US14928885
公开号：
US09714271B2
申请日:
2015.10.30
申请国别(地区):
US
年份:
2017
代理人:
摘要：
Analogs of cyclosporin-A are disclosed comprising modifications of the substituents as the positions of amino acids 1 and 3, according to the following Formula. The disclosed compounds include compounds having affinity for cyclophilin, including cyclophilin-A, and reduced immunosuppressivity in comparison with cyclosporin-A and analogs thereof modified solely at position 1.
