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Methods of treating cancer
专利权人:
GlaxoSmithKline LLC
发明人:
Creasy, Caretha L.,Ganji, Gopinath,McCabe, Michael T.,Smitheman, Kimberly N.
申请号:
AU2012315566
公开号:
AU2012315566A1
申请日:
2012.09.30
申请国别(地区):
AU
年份:
2014
代理人:
摘要:
This invention relates to methods of treating cancer in a subject in need thereof, e.g., in a human in need thereof, comprising determining at least one of the following in a sample from said human: (a) the presence or absence of a mutation at the alanine 677 (A677) residue in EZH2 in a sample from said human; or (b) the presence or absence of a mutation at the tyrosine 641 (Y641) residue in EZH2; or (c) the presence or absence of an increased level of H3K27me3 as compared to a control, and administering to said human an effective amount of an EZH2 inhibitor or a pharmaceutically acceptable salt thereof if at least one of said A677 mutation, Y641 mutation, or increased level of H3K27me3 is present in said sample.
来源网站:
中国工程科技知识中心
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