Caretha L. Creasy,Gopinath Ganji,Michael T McCabe,Kimberly N. Smitheman
申请号：
US14346359
公开号：
US09730925B2
申请日:
2012.09.30
申请国别(地区):
US
年份:
2017
代理人:
摘要：
This invention relates to methods of treating cancer in a subject such as a human and determining at least one of the following in a sample from the subject, such as a human: (a) the presence or absence of a mutation at the alanine 677 (A677) residue in EZH2 or (b) the presence or absence of a mutation at the tyrosine 641 (Y641) residue in EZH2 or (c) the presence or absence of an increased level of H3K27me3 as compared to a control, and administering to said human an effective amount of an EZH2 inhibitor or a pharmaceutically acceptable salt thereof if at least one of the A677 mutation, Y641 mutation, or increased level of H3K27me3 is present in the sample.
