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METHODS OF TREATING CANCER
专利权人:
发明人:
申请号:
EP12836842.0
公开号:
EP2760452A2
申请日:
2012.09.30
申请国别(地区):
EP
年份:
2014
代理人:
摘要:
This invention relates to methods of treating cancer in a subject such as a human and determining at least one of the following in a sample from the subject, such as a human: (a) the presence or absence of a mutation at the alanine 677 (A677) residue in EZH2 or (b) the presence or absence of a mutation at the tyrosine 641 (Y641) residue in EZH2 or (c) the presence or absence of an increased level of H3K27me3 as compared to a control, and administering to said human an effective amount of an EZH2 inhibitor or a pharmaceutically acceptable salt thereof if at least one of the A677 mutation, Y641 mutation, or increased level of H3K27me3 is present in the sample.
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