CREASY CARETHA L,GANJI GOPINATH,MCCABE MICHAEL T,SMITHEMAN KIMBERLY N
申请号：
IN2448/DELNP/2014
公开号：
IN2014DN02448A
申请日:
2014.03.28
申请国别(地区):
IN
年份:
2016
代理人:
摘要：
This invention relates to methods of treating cancer in a subject in need thereof e.g. in a human in need thereof comprising determining at least one of the following in a sample from said human: (a) the presence or absence of a mutation at the alanine 677 (A677) residue in EZH2 in a sample from said human or (b) the presence or absence of a mutation at the tyrosine 641 (Y641) residue in EZH2 or (c) the presence or absence of an increased level of H3K27me3 as compared to a control and administering to said human an effective amount of an EZH2 inhibitor or a pharmaceutically acceptable salt thereof if at least one of said A677 mutation Y641 mutation or increased level of H3K27me3 is present in said sample.
