CREASY, CARETHA L.,GANJI, GOPINATH,MCCABE, MICHAEL T.,SMITHEMAN, KIMBERLY N.
申请号：
CA2850570
公开号：
CA2850570A1
申请日:
2012.09.30
申请国别(地区):
CA
年份:
2013
代理人:
摘要：
This invention relates to methods of treating cancer in a subject in need thereof, e.g., in a human in need thereof, comprising determining at least one of the following in a sample from said human: (a) the presence or absence of a mutation at the alanine 677 (A677) residue in EZH2 in a sample from said human or (b) the presence or absence of a mutation at the tyrosine 641 (Y641) residue in EZH2 or (c) the presence or absence of an increased level of H3K27me3 as compared to a control, and administering to said human an effective amount of an EZH2 inhibitor or a pharmaceutically acceptable salt thereof if at least one of said A677 mutation, Y641 mutation, or increased level of H3K27me3 is present in said sample.
