TONER, JOHN L.,约翰L 透纳,約翰L 透納,BURKE, SANDRA E.,山卓E 布克,山卓E 布克,CROMACK, KEITH R.,凯斯R 克罗马克,凱斯R 克羅馬克,MACK, MATTHEW,马修 马克,馬修 馬克
申请号：
TW095137943
公开号：
TWI484952B
申请日:
2006.10.14
申请国别(地区):
TW
年份:
2015
代理人:
摘要：
Systems and compositions comprising paclitaxel and a second drug, such as rapamycin, analogs, derivatives, salts and esters thereof are disclosed, as well as methods of delivery wherein the drugs have effects that complement each other. Medical devices comprising supporting structures capable of including or supporting a pharmaceurically acceptable carrier or excipient, which carrier or excipient can contain one or more therapeutic agents or substances, with the carrier preferably including a coating on the surface thereof, and the coating including the therapeutic substances, such as, for example, drugs. Supporting structures for the medical devices that are suitable for use in this invention include coronary stents, peripheral stents, catheters, arterio-venous grafts, by-pass grafts, and drug delivery balloons used in the vasculature. These compositions and systems can be used in combination with other drugs, including anti-proliferative agents, anti-platelet agents, anti-inflammatory agents, anti-thrombotic agents, cytotoxic drugs, agents that inhibit cytokine or chemokine binding, cell de-differentiation inhibitors, anti-lipaedemic agents, matrix metalloproteinase inhibitors, cytostatic drugs, or combinations of these and other drugs.本發明揭示包含太平洋紫杉醇(paclitaxel)及第二藥物(諸如雷帕黴素、其類似物、衍生物、鹽及酯)之系統及組合物以及傳遞方法,其中該等藥物具有彼此互補之作用。本發明醫療裝置包含能包括或支撐醫藥學上可接受之載劑或賦形劑之支撐結構,該載劑或賦形劑可含有一或多種治療劑或物質,其中該載劑較佳包括其表面上之塗層,且該塗層包括該等諸如藥物之治療物質。適用於本發明醫療裝置之支撐結構包括用於維管結構中之冠狀動脈支架、周邊支架、導管、動脈-靜脈移植物、繞道移植物及藥物傳遞氣球。此等組合物及系統可與包括下列各物之其他藥物組合使用:抗增生劑、抗血小板藥、消炎藥、抗血栓形成劑、細胞毒性藥、抑制細胞激素或趨化激素結合之藥劑、細胞去分化抑制劑、抗血脂劑、基質金屬蛋白酶抑制劑、抑制細胞生長藥或此等藥物及其他藥物之組合。
