GURIJALA, VENU REDDY,BOLLU, SATYANARAYAN REDDY,LEBLANC, JACQUES,LOWINGER, TIMOTHY B.,MCGILLICUDDY, DENNIS,YIN, MAO,YURKOVETSKIY, ALEKSANDR V.
申请号：
CA3066754
公开号：
CA3066754A1
申请日:
2018.06.22
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
The disclosure provides methods of synthesis of polymeric scaffolds, e.g., those useful for conjugating with a protein based recognition- molecule (PBRM) to form PBRM-polymer-drug conjugates, and PBRM- polymer-drug conjugates thereof. The methods according to the disclosure allow for large-scale preparation of polymeric scaffolds having a high purity. In some embodiments, the methods according to the disclosure also allow for the preparation of scaffolds and conjugates thereof in better yield than previously used methods for preparing same. Also disclosed are methods of purifying polymeric scaffolds.
