YURKOVETSKIY, ALEKSANDR V.,YIN, MAO,LOWINGER, TIMOTHY B.,THOMAS, JOSHUA D.,STEVENSON, CHERI A.,GURIJALA, VENU R.
申请号：
CA2926586
公开号：
CA2926586A1
申请日:
2014.10.10
申请国别(地区):
CA
年份:
2015
代理人:
摘要：
A polymeric scaffold useful for conjugating with a protein based recognition-molecule (PBRM) to form a PBRM-polymer-drug conjugate is described herein. The scaffold includes one or more terminal maleimido groups. Also disclosed is a PBRM-polymer-drug conjugate prepared from the scaffold. Compositions comprising the conjugates, methods of their preparation, and methods of treating various disorders with the conjugates or their compositions are also described.
