YURKOVETSKIY ALEKSANDR,YIN MAO,LOWINGER TIMOTHY B,THOMAS JOSHUA D,HAMMOND CHARLES E,STEVENSON CHERI A,BODYAK NATALYA D,CONLON PATRICK R,GUMEROV DMITRY R
申请号：
IN2174/MUMNP/2013
公开号：
IN2013MN02174A
申请日:
2013.11.21
申请国别(地区):
IN
年份:
2015
代理人:
摘要：
A drug conjugate is provided herein. The conjugate comprises a protein based recognition molecule (PBRM) and a polymeric carrier substituted with one or more L D the protein based recognition molecule being connected to the polymeric carrier by L. Each occurrence of D is independently a therapeutic agent having a molecular weight = 5 kDa. L and L are linkers connecting the therapeutic agent and PBRM to the polymeric carrier respectively. Also disclosed are polymeric scaffolds useful for conjugating with a PBRM to form a polymer drug PBRM conjugate described herein compositions comprising the conjugates methods of their preparation and methods of treating various disorders with the conjugates or their compositions.
