The present invention relates to antibody, the antibody includes human antibody and its antigen-binding portion thereof, is specifically bound to MAdCAM, is preferably bonded to people MAdCAM, and acts on what and inhibit MAdCAM. The present invention also relates to people's anti-MAdCAM antibodies and its antigen-binding portion thereof. The present invention also relates to chimeric, bispecific, derivative, single-stranded antibody or fusion protein parts. The present invention also relates to the nucleic acid molecules of the isolated heavy chain and light chain immunoglobulins of source what people's anti-MAdCAM antibody and this immunoglobulin of coding. The present invention also relates to generate the method for people's anti-MAdCAM antibody, the composition containing these antibody and by the method for the antibody and composition what diagnosing and treating. The present invention is also provided with the gene therapy that coding constitutes the heavy chain of people's anti-MAdCAM antibody and/or the nucleic acid molecules of light chain immunoglobulin molecule. The present invention also relates to transgenic animals or plant comprising nucleic acid molecules of the present invention.本發明涉及抗體，所述的抗體包括人抗體和其抗原結合部分，其特異性結合至MAdCAM，優選結合至人MAdCAM，並作用於抑制MAdCAM。本發明也涉及人抗-MAdCAM抗體和其抗原結合部分。本發明也涉及嵌合的、雙特異性的、衍生的、單鏈的抗體或融合蛋白部分。本發明也涉及源於人抗-MAdCAM抗體的分離的重鏈和輕鏈免疫球蛋白和編碼這種免疫球蛋白的核酸分子。本發明也涉及産生人抗-MAdCAM抗體的方法、含有這些抗體的組合物和將該抗體和組合物用於診斷和治療的方法。本發明也提供使用編碼構成人抗-MAdCAM抗體的重鏈和/或輕鏈免疫球蛋白分子的核酸分子的基因療法。本發明也涉及包含本發明核酸分子的轉基因動物或植物。
