The present invention relates to antibodies including human antibodies and antigen-binding portions thereof that bind to P-cadherin, and that function to inhibit P-cadherin. The invention also relates to heavy and light chain immunoglobulins derived from human P-cadherin antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of making human P-cadherin antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions. The invention also relates to transgenic animals or plants comprising nucleic acid molecules of the present invention.本發明係關於結合於P－鈣黏素及用於抑制P－鈣黏素之抗體，包括人類抗體及其抗原結合部位。本發明亦係關於自人類P－鈣黏素抗體衍生之重鏈及輕鏈免疫球蛋白及編碼此等免疫球蛋白之核酸分子。本發明亦係關於製備人類P－鈣黏素抗體之方法、包含該等抗體之組合物及使用該等抗體及組合物之方法。本發明亦係關於包含本發明之核酸分子之轉殖基因動物或植物。
