The present invention relates to antibodies including human antibodies and antigen-binding portions thereof that specifically bind to MAdCAM, preferably human MAdCAM and that function to inhibit MAdCAM. The invention also relates to human anti-MAdCAM antibodies and antigen-binding portions thereof. The invention also relates to antibodies that are chimeric, bispecific, derivatized, single chain antibodies or portions of fusion proteins. The invention also relates to isolated heavy and light chain immunoglobulins derived from human anti-MAdCAM antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of making human anti-MAdCAM antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions for diagnosis and treatment. The invention also provides gene therapy methods using nucleic acid molecules encoding the heavy and/or light immunoglobulin molecules that comprise the human anti-MAdCAM antibodies. The invention also relates to transgenic animals or plants comprising nucleic acid molecules of the invention.本發明係關於特異性地結合至MAdCAM(以人類MAdCAM為較佳)且發揮作用以抑制MAdCAM之抗體(包括人類抗體)及其抗原結合部分。本發明亦係關於一種人類抗MAdCAM抗體及其抗原結合部分。本發明亦關於一種，其係嵌合、雙特異、衍生化的、單鏈抗體或部分之融合抗體。本發明亦關於一種經分離之源自人類抗MAdCAM抗體的重鏈及輕鏈免疫球蛋白及編碼該等免疫球蛋白之核酸分子。本發明亦係關於製造人類抗MAdCAM抗體之方法、包含該等抗體之組合物及使用該等抗體及組合物而供用於診斷及治療之方法。本發明亦提供一種使用編碼包含人類抗MAdCAM抗體之重及/或輕免疫球蛋白分子之核酸分子的基因治療方法。本發明亦關於一種包含本發明之核酸分子的轉基因動物或植物。
