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A novel 5H-pyrrolo [2,3-d] pyrimidin-6 (7H) -one derivative
专利权人:
다이호야쿠힌고교 가부시키가이샤
发明人:
스기모토, 테츠야,사카모토, 토시히로,야마모토, 후유키,코바야카와, 유,에가시라, 나오키,이치카와, 코지,마치다, 타쿠미츠
申请号:
KR1020187030344
公开号:
KR1020180120777A
申请日:
2017.05.19
申请国别(地区):
KR
年份:
2018
代理人:
摘要:
An inhibitory effect on at least one member selected from the group consisting of Akt kinase, Rsk kinase and S6K kinase, and / or cell proliferation inhibitory effect. Further, the present invention provides a medicament useful for the prevention and / or treatment of diseases associated with at least one selected from the group consisting of Akt kinase, Rsk kinase and S6K kinase according to the inhibitory action, particularly cancer. In the formula (I), R 1 is a 4 to 6 member monocyclic group having 1 to 3 heteroatoms selected from N, S and O, which may have a substituent group An unsaturated heterocycle group; R 2 represents a hydrogen atom, a halogen atom, a hydroxyl group, an amino group, a cyano group, a nitro group, a C 1 -C 6 alkyl group, a C 1 -C 6 haloalkyl group, A C2-C6 alkenyl group or a C2-C6 alkynyl group; R 3 , R 4 and R 5 are the same or different and represent a hydrogen atom, a halogen atom, a hydroxyl group, an amino group, a cyano group, a nitro group, a C 1 -C 6 alkyl group, a C 1 -C 6 haloalkyl group, a C 2 -C 6 alkenyl group, C6 alkynyl group; Or R 3 and R 4 together with the nitrogen atom to which they are attached form a 4- to 6-membered monocyclic saturated heterocycle having 1 to 3 heteroatoms selected from N, S and O and R 5 is the same or carry, A halogen atom, a hydroxyl group, an amino group, a cyano group, a nitro group, a C1-C6 alkyl group, a C1-C6 haloalkyl group, a C2-C6 alkenyl group or a C2-C6 alkynyl group; Or R 4 and R 5 form a 4 to 6 membered monocyclic saturated heterocycle having 1 to 3 heteroatoms selected from N, S and O together with the nitrogen atom to which they are bonded and the adjacent carbon atom, and R 3 is A halogen atom, a hydroxyl group, an amino group, a cyano group, a nitro group, a C1-C6 alkyl group, a C1-C6 haloalkyl group, a C2-C6 alkenyl group and a C2-C6 alkynyl group; R 6 is a hydrogen atom, a halogen atom, a hydroxyl group, an amino group, a cyano group, a nitro group, a C 1 -C 6 alkyl group, a C 1 -
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