The invention relates to compounds that have utility in decreasing body fat of for preventing or decreasing the accumulation of body fat in a subject, and which inhibit the enzyme stearoyl-coenzymeA desaturase (SCD). The compounds have Formula I where R1 is a C1 to C8 linear, branched or cyclic alkyl or alkenyl group having up to two double bonds, and optionally substituted with one or more groups selected from (i) one or more halogen atoms (ii) alkoxy group of formula OR6 (iii) hydroxy and (iv) carboxyl group of formula COOR7 R2, R2, R3, R3 are independently and for each occurrence selected from (a) hydrogen (b) C1 to C4 alkyl optionally substituted with one or more groups selected from (i) to (iii) above (c) halogen and (d) C1-C2 alkoxy. Where R2 and R2 are both selected from either (b) or (d), R2 and R2 can optionally be linked. Where R3 and R3 are both selected from either (b) or (d), R3 and R3 can optionally be linked R4 and R5 are each independently selected from hydrogen and C1 to C4 alkyl optionally substituted with one or more groups selected from (i) to (iii) above R6 is selected from linear, branched or cyclic C1 to C4 alkyl optionally substituted with one or more halogen atoms R7 is selected from hydrogen and linear, branched or cyclic C1 to C4 alkyl and x is an integer from 1 to 3.
