GRAY, JEFFREY LYLE,MAIER, MATHEW BRIAN,CLARK, CYNTHIA MONESA,AMARASINGHE, KANDE,NICHOLS, RYAN
申请号：
ES07809907
公开号：
ES2525429T3
申请日:
2007.06.27
申请国别(地区):
ES
年份:
2014
代理人:
摘要：
A compound having the formula: ** Formula ** where R is a substituted or unsubstituted thiazolyl unit having the formula: ** FORMULA ** each of R4 and R5 is independently selected from: i) hydrogen, methyl or ethyl； or ii) when R5 is hydrogen and R4 is linear, branched, or substituted or unsubstituted C1-C6 alkyl, said substitutions are selected from -15 N (R11) 2, -OR11, fluorine, chlorine, bromine and iodine, each R11 is independently hydrogen, linear or branched C1-C4 alkyl； iii) substituted or unsubstituted phenyl； or iv) substituted or unsubstituted 5-membered or 6-membered heteroaryl, where at least one of the atoms in the ring is a heteroatom selected from nitrogen, oxygen, or sulfur； or R4 and R5 can be taken together to form a saturated or unsaturated ring having 5 to 7 atoms； said substitutions are independently selected from one or more linear, branched, or cyclic, halogen, hydroxyl, or cyano C1-C6 alkyl units； or are selected from -CH2OH, -OCH3, -CH2OCH3, -OCH2CH3, -CH2OCH2CH3, -OCH2CH2CH3, and -CH2OCH2CH2CH3； or are selected from -NH2, -CH2NH2, -NHCH3, -N (CH3) 2, -NH (CH2CH3), -CH2NHCH3, -CH2N (CH3) 2, and -CH2NH (CH2CH3)； R6 is a unit selected from: i) hydrogen； ii) C1-C6 linear, branched, or substituted or unsubstituted cyclic alkyl； iii) substituted or unsubstituted phenyl where the substituted phenyl units are selected from 2-fluorophenyl, 2-chlorophenyl, 2-methylphenyl, 2-methoxyphenyl, 3-fluorophenyl, 3-chlorophenyl, 3-methylphenyl, 3-methoxyphenyl, 4- fluorophenyl, 4-chlorophenyl, 4-methylphenyl, 4-methoxyphenyl； or iv) substituted or unsubstituted 5-membered or 6-membered heteroaryl, where at least one of the atoms in the ring is a heteroatom selected from nitrogen, oxygen, or sulfur； said substitutions are independently selected from one or more linear, branched, or cyclic, halogen, hydroxyl, or cyano C1-C6 alkyl units； or are selected from -CH2OH, -OCH3, -CH2OCH3, -OCH2CH3, -CH2OCH2CH3, -OCH2CH2CH3, and -CH2OCH2CH2CH3； or are selected from -N
