FIELD: chemistry.SUBSTANCE: invention relates to a compound of formula,where R denotes a substituted or unsubstituted thiazolyl group of formula or ； R4 and R5, each independently, are selected from i) hydrogen； ii) a substituted or unsubstituted C1-C6 linear, C3-C6 branched or C3-C6 cyclic alkyl； iii) a substituted or unsubstituted phenyl； iv) a substituted or unsubstituted heteroaryl containing 5 or 6 ring atoms and 1 or 2 heteratoms, where the heteroatoms are selected from nitrogen, oxygen, sulphur and combination thereof； or R4 and R5 can be taken together to form a saturated or unsaturated ring, having 5-7 atoms； said substitutes are independently selected from one or more groups, selected from C1-C6 linear, C3-C6 branched or C3-C6 cyclic alkyl, halogen, hydroxyl or cyano； R6 denotes a group selected from i) hydrogen； ii) a substituted or unsubstituted C1-C6 linear, C3-C6 branched or C3-C6 cyclic alkyl； iii) a substituted or unsubstituted phenyl or iv) a substituted or unsubstituted heteroaryl containing 5 or 6 ring atoms and 1 or 2 heteroatoms, where the heteroatoms are selected from nitrogen, oxygen, sulphur and combination thereof； where said substitutes are independently selected from one or more groups selected from C1-C6 linear, C3-C6 branched or C3-C6 cyclic alkyl, halogen, hydroxyl or cyano； R1 is selected from i) hydrogen； ii) C1-C6 linear or C3-C6 branched alkyl； iii) a substituted or unsubstituted phenyl or iv) a substituted or unsubstituted benzyl； where said substitutes are independently selected from one or more groups selected from C1-C6 linear, C3-C6 branched or C3-C6 cyclic alkyl, halogen, hydroxyl or cyano； R2 is selected from i) C1-C6 linear or C3-C6 branched alkyl or ii) C1-C6 linear or C3-C6 branched alkoxy； R3 denotes hydrogen or C1-C4 linear or C3-C6 branched alkyl.EFFECT: compounds of formula (I) are effective as human protein tyrosine phosphatase beta (HPTP-β) inhibitors.20 cl, 10 tbl, 8 exИзобретение относится к соединению, имеющему
