CHOI, Soongyu (KR),КИМ Моонсоо (KR),KIM, Misoon (KR),ЛИ Чаевоон (KR),LEE, Jae, Il (KR),ЛИ Гилнам (KR),KIM, Hye, Kyoung (KR),ЙООН Чеолхван (KR),KIM, Hyun, Jung (KR),СЕО Дзеонгбеоб (KR),LEE, Ki, Nam (KR
申请号：
RU2017125025
公开号：
RU0002708674C2
申请日:
2015.12.14
申请国别(地区):
RU
年份:
2019
代理人:
摘要：
FIELD: chemistry.SUBSTANCE: invention relates to novel compounds of general formula I or a pharmaceutically acceptable salt thereof. In a compound of formula I,IR1 is a phenyl ring substituted with one or more substituents independently selected from a group consisting of fluorine, methoxy and ethoxy； R2 is H； X is selected from a group consisting of -CH2- and -CH(Z)-, where Z is halogen； and Q is selected from a group consisting of -CH=CR3C(O)NR4R5, -C≡CC (O) NR4R5 and； where R3 is H, where -NR4R5 either forms 4–7-member heterocyclic ring or does not form a ring structure, wherein the heterocyclic ring is 4–7-member heterocycloalkyl ring, where when -NR4R5 forms 4- to 7-member heterocyclic ring, 4–7 membered heterocyclic ring optionally includes a second heteroatom selected from N or O in addition to nitrogen in -NR4R5, and is optionally substituted with one or more substituents, independently selected from a group consisting of linear C1-C6 alkyl, branched C1-C6 alkyl, hydroxyl, where when -NR4R5 does not form a ring structure, then R4 is selected from a group consisting of hydrogen, linear C1-C6 alkyl and branched C1-C6 alkyl, linear C1-C6 hydroxyalkyl and branched C1-C6 hydroxyalkyl, and R5 is selected from H, methyl, ethyl, isopropyl, cyclopropyl, tert-butyl, methoxyethyl and hydroxyethyl, where each of Y1, Y2, Y3 and Y4 is independently selected from a group consisting of -CH, N, O, S, -CR6 and -NR6, provided that three of Y1, Y2, Y3 and Y4 are selected from N or NR6, or one of Y1, Y2, Y3 and Y4 is O or S, and one or two of Y1, Y2, Y3 and Y4 are N or NR6, where R6 is selected from a group consisting of hydrogen, linear C1-C4 alkyl, branched C1-C4 alkyl, 5-member heteroaryl ring having 2 nitrogen atoms in the ring, 5–7-member heterocycloalkyl ring having 1 to 2 nitrogen atoms and/or oxygen in ring, 3–7-member cycloalkyl ring, -NHCO- (phenyl ring) and -CH2CO- (6-member heterocyclic ring having 1–2 heteroatoms selected from nitrogen and oxygen)； or R1 is a pyridi
