GRAY, JEFFREY LYLE,CLARK, CYNTHIA,AMARASINGHE, KANDE,MAIER, MATHEW BRIAN,NICHOLS, RYAN
申请号：
ES07809909
公开号：
ES2510674T3
申请日:
2007.06.27
申请国别(地区):
ES
年份:
2014
代理人:
摘要：
A compound of formula I: ** Formula ** in which R is a unit selected from: i) hydrogen； ii) phenyl； and iii) thiophene-2-yl, Z is a substituted or unsubstituted thiadiazol-2-yl [1,3,4] unit of formula: R1 is selected from: i) hydrogen； ii) linear, branched or cyclic C1-C6 alkyl； iii) substituted or unsubstituted C6 or C10 aryl, wherein the substitutions are selected from halogen, methyl, ethyl, isopropyl, amino, methylamino, dimethylamino and ethylamino； iv) 2-cyanophenyl, 3-cyanophenyl, 4-cyanophenyl, 2-nitrophenyl, 3-nitrophenyl, 4-nitrophenyl； v) -OR4； vi) -C (O) OR5； vii) -COR6； or viii) -NR 7C (O) OR8； R4 is hydrogen or linear, branched or cyclic C1-C6 alkyl； R5 is linear or branched C1-C6 alkyl, or benzyl； R6 is linear, branched or cyclic C1-C6 alkyl, or phenyl； R7 is hydrogen or methyl； R8 is linear or branched C1-C6 alkyl, or benzyl； L is a unit of formula - [C (R9aR9b)] and-； when L is a unit of formula -CH2-, R1 can also be selected from substituted or unsubstituted thiazol-4-yl, said substitutions being selected from methyl, ethyl, fluorine and chlorine, each of R9a and R9b is independently hydrogen, C1 alkyl -C6 linear or branched, or phenyl； and the index x is 0 or 1； the index y is from 1 to 4； or a pharmaceutically acceptable salt thereof.Un compuesto de fórmula I:**Fórmula** en la que R es una unidad seleccionada entre: i) hidrógeno； ii) fenilo； y iii) tiofen-2-ilo, Z es una unidad [1,3,4]tiadiazol-2-ilo sustituida o no sustituida de fórmula : R1 se selecciona entre: i) hidrógeno； ii) alquilo C1-C6 lineal, ramificado o cíclico； iii) arilo C6 o C10 sustituido o no sustituido, en el que las sustituciones se seleccionan entre halógeno, metilo, etilo, isopropilo, amino, metilamino, dimetilamino y etilamino； iv) 2-cianofenilo, 3-cianofenilo, 4-cianofenilo, 2-nitrofenilo, 3-nitrofenilo, 4-nitrofenilo； v) -OR4； vi) -C(O)OR5； vii) -COR6； o viii) -NR 7C(O)OR8； R4 es hidrógeno o alquilo C1-C6 lineal, ramificado o cíclico； R5 es alquilo C1-C6 lineal o ramificad
