GRAY, JEFFREY LYLE,AMARASINGHE, KANDE,CLARK, CYNTHIA MONESA,MAIER, MATTHEW BRIAN,NICHOLS, RYAN
申请号：
ES07809908
公开号：
ES2534392T3
申请日:
2007.06.27
申请国别(地区):
ES
年份:
2015
代理人:
摘要：
A compound of the formula: ** Formula ** in which R is a substituted or unsubstituted thiazolyl unit of the formula: ** Formula ** each of R2 and R3 is independently selected from: ** Formula ** i) hydrogen； ii) substituted or unsubstituted linear, branched or cyclic C1-C6 alkyl； iii) substituted or unsubstituted phenyl； or iv) substituted or unsubstituted 5-membered or 6-membered heteroaryl ring, where at least one ring atom is a heteroatom selected from nitrogen, oxygen and sulfur； or R2 and R3 can be taken together to form a saturated or unsaturated ring having 5 to 7 atoms； R4 is a unit selected from: i) hydrogen； ii) substituted or unsubstituted linear, branched or cyclic C1-C6 alkyl； iii) substituted or unsubstituted phenyl； or iv) substituted or unsubstituted 5-membered or 6-membered heteroaryl ring, where at least one ring atom is a heteroatom selected from nitrogen, oxygen and sulfur； said substitutions for R, R2, R3, and R4 are independently selected from one or more linear, branched or cyclic C1-C6 alkyl, -N (R16) 2, -OR16, halogen, or cyano units； each R16 is independently hydrogen, linear, branched or cyclic C1-C4 alkyl； Z is a unit of formula: R1 is selected from: i) hydrogen； ii) substituted or unsubstituted linear, branched or cyclic C1-C6 alkyl； iii) substituted or unsubstituted C6 aryl, where each substitution is independently selected from halogen, linear, branched or cyclic C1-C4 alkyl, -OR11, -CN, -N (R11) 2, -CO2R11, -C (O) N (R11) 2, -NR11C (O) R11, -NO2 and -SO2R11, each R11 is independently hydrogen, alkyl, alkenyl or C1-C4 linear, branched or cyclic substituted or unsubstituted alkynyl； substituted or unsubstituted phenyl or benzyl； or two R11 units can be taken together to form a ring comprising 3-7 atoms； iv) substituted or unsubstituted C1-C9 heterocyclic rings, where the heteroatoms are selected from nitrogen, oxygen and sulfur； or v) substituted or unsubstituted C1-C9 heteroaryl rings, where at least one atom in the ring is a heteroato
