118672233141222 2233334514614 14The invention relates to compounds that have utility in decreasing body fat or for preventing or decreasing the accumulation of body fat in a subject and which inhibit the enzyme stearoyl coenzymeA desaturase (SCD). The compounds have Formula I where R is a C to C linear branched or cyclic alkyl or alkenyl group having up to two double bonds and optionally substituted with one or more groups selected from (i) one or more halogen atoms (ii) alkoxy group of formula OR (iii) hydroxy and (iv) carboxyl group of formula COOR R R R R are independently and for each occurrence selected from (a) hydrogen (b) C to C alkyl optionally substituted with one or more groups selected from (i) to (iii) above (c) halogen and (d) C C alkoxy. Where R and Rare both selected from either (b) or (d) R and R can optionally be linked. Where R and R are both selected from either (b) or (d) R and R can optionally be linked R and R are each independently selected from hydrogen and C to C alkyl optionally substituted with one or more groups selected from (i) to (iii) above R is selected from linear branched or cyclic C to Calkyl optionally substituted with one or more halogen atoms R7 is selected from hydrogen and linear branched or cyclic C to C alkyl and x is an integer from 1 to 3.
