1. A method for preventing patient metastases, comprising contacting a patient with an effective amount of a compound having the formula: wherein R is a substituted or unsubstituted thiazolyl group having the formula: R, R, and R are each independently: i) hydrogen； ii) substituted or unsubstituted C-linear , C-Branched or C-Cyclic alkyl； iii) substituted or unsubstituted C-C linear, C-Branched or C-Cyclic alkenyl； iv) substituted or unsubstituted C-C linear or C-Branched alkynyl； v) substituted or unsubstituted C or C rilom； vi) substituted or unsubstituted C-Cgeteroarilom； vii) substituted or unsubstituted C-Cgeterotsiklom； or viii) R and R may be taken together to form a saturated or unsaturated ring containing from 5 to 7 atoms； where from 1 to 3 atoms may optionally be heteroatoms selected from oxygen, nitrogen and sulfur； Z is a group having the formula: R are selected from: i) hydrogen； ii) hydroxyl； iii) amino； iv) substituted or unsubstituted C-linear, C-branched or C-cyclic alkyl； v) substituted or unsubstituted C-linear, C-branched or C-cyclic alkoxy； vi) substituted or unsubstituted Caryl； vii) substituted or unsubstituted C-C heterocyclic ring； or viii) a substituted or unsubstituted C-C heteroaryl ring； L is a linking group having the formula: - [Q] [C (RR)] [Q] [C (RR)] - Q and Q is each independently: i) -C (O ) -； ii) -NH-； iii) -C (O) NH-； iv) -NHC (O) -； v) -NHC (O) NH-； vi) -NHC (O) O-； vii) -C (O) O-； viii) -C (O) NHC (O) -； ix) -O-； x) -S-； xi) -SO-； xii) -C (= NH) -； xiii ) -C (= NH) NH-； xiv) -NHC (= NH) -； or xv) —NHC (═NH) NH—； R and R each independently are: i) hydrogen； ii) hydroxy； iii) halogen； iv) substituted or unsubstituted C-linear or C-branched alkyl； or v)1. Способ предупреждения метастазов у пациента, включающий контакт пациента с эффективным количеством соединения, имеющего формулу:где R является замещенной или незамещенной тиазолильной группой, имеющей формулу:R, Rи Rкаждый независимо является:i) водородом；ii) замещенным или не
