1. A method of treating vascular leakage syndrome, comprising contacting a subject in need of treatment with an effective amount of a compound having the formula: wherein R is a substituted or unsubstituted thiazolyl element having the formula: each of R, R and R is independently: i) hydrogen； ii) substituted or unsubstituted C-linear, C-branched or C-cyclic alkyl； iii) substituted or unsubstituted C-linear, C-branched or C-cyclic alkenyl； iv) substituted or unsubstituted C-linear or C-branched alkynyl； v) substituted or unsubstituted Cily Caryl； vi) substituted or unsubstituted C-Ceteroaryl； vii) substituted or unsubstituted C-Ceterocycle； or viii) R and R taken together can form a saturated or unsaturated ring having from 5 to 7 atoms, where from 1 to 3 atoms can optionally be heteroatoms selected from oxygen, nitrogen and sulfur. Z is an element having the formula: - (L) nR, R are selected from: i) hydrogen； ii) hydroxyl； iii) amino； iv) substituted or unsubstituted C-linear, C-branched or C-cyclic alkyl； v) substituted or unsubstituted C-linear, C- Branched or C-Cyclic alkoxy； vi) substituted or unsubstituted Caryl Caryl； vii) substituted substituted or unsubstituted C-C heterocyclic rings； or viii) substituted or unsubstituted C-C heteroaryl rings； L is a connecting element having the formula: - [Q] [C (RR)] [Q] [C (RR)] -, each of Q and Q independently represents: i) —C (O) -； ii) —NH—； iii) —C (O) NH—； iv) —NHC (O) -； v) —NHC (O) NH—； vi ) -NHC (O) O-； vii) -C (O) O-； viii) -C (O) NHC (O) -； ix) -O-； x) -S-； xi) -SO-； xii) -C (= NH) -； xiii) -C (= NH) NH-； xiv) -NHC (= NH) - or xv) -NHC (= NH) NH-； each of R and R independently represents: i) hydrogen； ii) hydroxy； iii) halogen1. Способ лечения синдрома сосудистой утечки, включающий контактирование нуждающегося в лечении субъекта с эффективным количеством соединения, имеющего формулу:где R представляет собой замещенный или незамещенный тиазолильный элемент, имеющий формулу:каждый из R, Rи Rнезависимо представ
