Annie Mayence;Tien Liang Huang;Peter D. Walzer;Melanie T. Cushion;Jean Jacques Vanden Eynde
发明人:
Peter D. Walzer,Melanie T. Cushion,Annie Mayence,Tien Liang Huang,Jean Jacques Vanden Eynde
申请号：
US13050169
公开号：
US08912359B2
申请日:
2011.03.17
申请国别(地区):
US
年份:
2014
代理人:
摘要：
A method of combating infectious agents, such as Pneumocystis pneumonia, and a method of treating a subject in need of such treatment is disclosed. The method comprises administering to the subject a bis-benzamidoxime of formula I wherein the linker is a di-substituted cyclic moiety of any ring size and may contain at least one heteroatom； the aromatic group is 1,2-； 1,3-； or 1,4-disubstituted； R is selected from the group consisting of a hydrogen, a linear or branched alkyl group, containing from 1 to 20 carbon atoms； R′ is selected from the group consisting of a hydrogen, a linear or branched alkyl group containing from one to twenty carbon atoms, an aromatic ring, a cycloalkyl group containing three to eight carbon atoms, or a hydroxyl group； alternatively, R and R′ may form a cyclic structure that can be fused to another cyclic system； or a pharmaceutically acceptable salt thereof. Pharmaceutical formulations and active compounds useful in the practice of the present invention are also disclosed.
