KAVAMOTO Richard Masaru (US),КАВАМОТО Ричард Масару (US),BOJER Anzhelik San (US),БОЙЕР Анжелик Сан (US),GREJZ Kennet Donal'd (US),ГРЕЙЗ Кеннет Дональд (US),EVDOKIMOV Artem G. (US),ЕВДОКИМОВ Артем Г. (,ЕВДОКИМОВ Артем Г. (US),ВУ Шэндэ (US),ВАРШАКУН Намал Читранга (US)
申请号：
RU2009102220/04
公开号：
RU0002429226C9
申请日:
2007.06.26
申请国别(地区):
RU
年份:
2013
代理人:
摘要：
FIELD: chemistry.SUBSTANCE: invention relates to a compound of formula, where R and R1 independently denote a link selected from: i) hydrogen； ii) substituted or unsubstituted phenyl and iii) substituted or unsubstituted 5- or 6-member heteroaryl in which heteroatoms are selected from nitrogen, oxygen, sulphur or combinations thereof； said substitutes are selected from: i) C1-C4 linear, C3-C4 branched or C3-C4 cyclic alkyl； ii) C1-C4 linear, C3-C4 branched or C3-C4 cyclic alkoxy； iii) C1-C4 linear, C3-C4 branched or C3-C4 cyclic halogenalkyl； iv) halogen； v) -CN； vi) -NHC(O)R4 vii) -C(O)NR5aR5b； viii) 5- or 6-member heteroaryl in which heteroatoms are selected from nitrogen, oxygen, sulphur or combinations thereof； or ix) two substitutes may be taken together to form a condensed ring containing 5-7 atoms； R4 is C1-C4 linear, C3-C4 branched or C3-C4 cyclic alkyl； R5a and R5b each independently denotes: 1) hydrogen； ii) C1-C4 linear, C3-C4 branched or C3-C4 cyclic alkyl； or iii) R5a and R5b can be taken together to form a ring containing 3-7 atoms； R2 is selected from: i) -OR6； or ii) -NR7aR7b； R6 is hydrogen or C1-C4 linear, C3-C4 branched or C3-C4 cyclic alkyl； R7a and R7b each independently denotes: i) hydrogen； ii) C1-C4 linear, C3-C4 branched or C3-C4 cyclic alkyl； or iii) R7a and R7b may be taken together to form a ring containing 3-7 atoms； R3 is hydrogen, methyl or ethyl； L is a binding link of formula -[C(R8aR8b)]n -R8a and R8b each independently denotes hydrogen, methyl or ethyl； n ranges from 1 to 3； R9 is hydrogen or methyl； or pharmaceutically acceptable salt thereof； provided that R and R1 both denote hydrogen. The invention also relates to compositions based on the described compounds for treating anaemia or assisting wound healing and use of said compounds to prepare a composition for treating anaemia or wounds.EFFECT: novel compounds which are HIF-16 prolyl hydroxylase inhibitors are obtained.14 cl, 18 ex, 15 tbl, 2 dwgНастоящее изобретение относитс
