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АНТИКОАГУЛЯНТНЫЕ СОЕДИНЕНИЯ И ИХ ПРИМЕНЕНИЕ
专利权人:
ХАОМАМЕДИКА ЛИМИТЕД (GB)
发明人:
ХОДЖЕС Стивен (GB),СОПЕР Робин (GB)
申请号:
RU2012130932/04
公开号:
RU2012130932A
申请日:
2010.12.22
申请国别(地区):
RU
年份:
2014
代理人:
摘要:
1. A compound of formula (I):whereinR1 It represents hydrogen, halogen, cyano, trifluoromethyl, nitro, -ORa, SRa, SORa, -SO2Ra, -SO2NRaRb, -NRaRb, -NRaCORb, -NRaCO2Rb, -CORa, -CO2Ra, -CONRaRb or a hydrocarbon group containing a linear, branched or cyclic moiety, each containing up to 18 carbon atoms, or a heterocyclic group containing up to 18 carbon atoms and at least one heteroatomR2Independently each occurrence is hydrogen, halogen, cyano, trifluoromethyl, nitro, -ORa, SRa, SORa, -SO2Ra, SO2NRaRb, -NRaRb, -NRaCORb, -NRaCO2Rb, -CORa, -CO2Ra, -CONRaRb or a hydrocarbon group containing a linear, branched or cyclic moiety, each containing up to 18 carbon atoms, or a heterocyclic group containing up to 18 carbon atoms and at least one heteroatomR3 represents a hydrocarbon group containing a linear, branched or cyclic moiety, each containing up to 18 carbon atoms and substituted by at least one substituent, including a substituent -CO2Rawherein each of the substituents Ra and RbIndependently each occurrence is hydrogen or a hydrocarbon group containing a linear, branched or cyclic moiety, each containing up to 18 carbon atoms, or a heterocyclic group containing up to 18 carbon atoms and at least one heteroatom andn is 0, 1, 2, 3 or 4or a pharmaceutically acceptable solvate thereof, or, more preferably, the corresponding salt or prodrug thereofas anticoagulant.2. Use of compounds according to claim 1, whereinR1 or R2 It represents hydrogen, halogen, cyano, trifluoromethyl, nitro, -ORa, SRa, SORa, -SO2Ra, -SO2NRaRb, -NRaRb, -NRaCORb, -NRaCO2Rb, -CORa, -CO2Ra, -CONRaRb or a hydrocarbon group containing a linear, branched or cyclic moiety, each containing up to 18 carbon atoms, or a heterocyclic group containing up to 18 carbon atoms and at least one heteroatomR3 represents a hydrocarbon group containing a linear, branched or cyclic moiety, each containing up to 18 carbon atoms and substituted by at least one substituent, including a substituent -CO2Rawherein the substitue
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