SU VEHJ-GO,СУ Вэй-Го,DEHN VEHJ,ДЭН Вэй,LI TSZINSHUJ,ЛИ Цзиньшуй,TSZI TSZJANGO,ЦЗИ Цзяньго
申请号：
RU2013104520/04
公开号：
RU0002563644C2
申请日:
2011.08.18
申请国别(地区):
RU
年份:
2015
代理人:
摘要：
FIELD: medicine, pharmaceutics.SUBSTANCE: invention relates to pyrrolopyrimidine compounds of formula (I), which possess properties of an inhibitor of at least one kinase, selected from JAK1, JAK2, JAK3 and TYK2, or their pharmaceutically acceptable salt. In formula (I) compound:,R1 is selected from hydrogen, C1-C4alkyl, C3-C6cycloalkyl R2 is selected from aryl, heterocycle, heteroaryl, -C(O)NRcRd, -S(O)nRf and -S(O)nNRcRd, and each of the said alkyl, aryl, cycloalkyl, heterocycle, heteroaryl in R1 and R2 is possibly substituted with one or more groups, selected from a possibly substituted C1-C4alkyl, possibly substituted aryl, possibly substituted C2-C6alkinyl, C3-C6cycloalkyl, -C(O)ORb, -CN, -C(O)NRcRd, halogen, possibly substituted heterocycle, possibly substituted heteroaryl, NRcRd, -NReC(O)Ra, -NReS(O)nRf, -NO2, -ORb, -S(O)nRf and -S(O)nNRcRd m equals 1 and n equals 2 in each case Ra, Rb, Rc, Rd, Re and Rf each is independently selected from hydrogen, possibly substituted C1-C4alkyl, possibly substituted C2-C6alkinyl, possibly substituted C3-C6cycloalkyl, possibly substituted aryl, possibly substituted heteroaryl and possibly substituted heterocycle or Rc and Rd with a nitrogen atom, which they are bound to, form a heterocyclic ring, which is possibly substituted with one or more groups, selected from halogen, C1-C4alkyl, hydroxyl and C1-C4alkoxy, where the heterocyclic ring also possibly contains one or two additional heteroatoms, selected from N, O and S where each possibly substituted the said group can be non-substituted or independently substituted with one or more substituents, independently selected from C1-C4alkyl, C3-C6cycloalkyl, aryl, heterocycle, C1-C4haloalkyl, -OC1-C4alkyl, -C1-C4alkyl-O-C1-C4alkyl, halogen, -OH, -NH2, -N(C1-C4alkyl)(C1-C4alkyl), -CN, and -NO2, in which each aryl, heterocycle are possibly substituted with one or more groups, selected from halogen and C1-C4alkyl.EFFECT: obtaining a medication for the treatment of an inflammatory di
