GRUNDL, Marc,DOLLINGER, Horst,GIOVANNINI, Riccardo,HOENKE, Christoph,HOFFMANN, Matthias,KRIEGL, Jan,MARTYRES, Domnic,RAST, Georg,SEITHER, Peter
申请号：
ES10712432
公开号：
ES2613696T3
申请日:
2010.04.01
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
A compound of formula 1, ** Formula ** in which A is CH2, O or N- C1-6 alkyl； R1 is selected from - NHR1.1 or NMeR1.1； - NHR1.2 or NMeR1.2； - NHCH2-R1.3； - C3-6 NH-cycloalkyl, while, optionally, a carbon atom is replaced by a nitrogen atom, while the ring is optionally substituted with one or more moieties selected from the group consisting of C1-6 alkyl, O -C1-6 alkyl, NHSO2-phenyl, NHCONH-phenyl, halogen, CN, SO2-C1-6 alkyl and COO-C1-6 alkyl； - a C9 or 10 bicyclic ring, while one or two carbon atoms are replaced by nitrogen atoms and the ring system is joined by a nitrogen atom to the basic structure of formula 1 and while the ring system is optionally substituted with one or more moieties selected from the group consisting of C1-6 alkyl, COO-C1-6 alkyl, C1-6 haloalkyl, O- C1-6 alkyl, NO2, halogen, CN, NHSO2-C1-6 alkyl and methoxyphenyl； - a group selected from NHCH (pyridinyl) CH2COO-C1-6 alkyl and NHCH (CH2O-C1-6 alkyl) -benzoimidazolyl, optionally substituted by halogen or CN； - or 1-aminocyclopentyl, optionally substituted with methyl oxadiazole； R1.1 is phenyl, optionally substituted with one or more moieties selected from the group consisting of C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C1-6-OH alkylene, C2- alkenylene 6-OH, C2-6-OH alkynylene, CH2CON (C1-6 alkyl) 2, CH2NHCONH-C3-6 cycloalkyl, CN, CO-pyridinyl, CONR1.1.1R1.1.2, COO-C1-6 alkyl, N (SO2 -C1-6 alkyl) (CH2CON (C1-4 alkyl) 2) O-C1-6 alkyl, O-pyridinyl, SO2-C1-6 alkyl, SO2-C1-6 alkylene-OH, SO2-C3-6 cycloalkyl, SO2-piperidinyl, SO2NH-C1-6 alkyl, SO2N (C1-6 alkyl) 2, halogen, CN, CO-morpholinyl, CH2-pyridinyl or a heterocyclic ring optionally substituted with one or more moieties selected from the group consisting of alkyl C1-6, NH C1-6alkyl and>； = O； R1.1.1 H, C1-6 alkyl, C3-6 cycloalkyl, C1-6 haloalkyl, CH2CON (C1-6 alkyl) 2, CH2CO-azetindinyl, C1-6 alkylene-C3-6 cycloalkyl, CH2-pyranyl, CH2-tetrahydrofuranyl , CH2-furanyl, C1-6-alkylene or thiadiazolyl, optionally substituted wi
