BOURKE, David Gerard,BURNS, Christopher John,CUZZUPE, Anthony Nicholas,FEUTRILL, John Thomas,KLING, Marcel Robert,NERO, Tracy Leah
申请号：
ES08849455
公开号：
ES2564422T3
申请日:
2008.11.14
申请国别(地区):
ES
年份:
2016
代理人:
摘要：
A compound of formula Ib ** Formula ** in which Z is NR2 or S； A and B independently are absent or are a substituted or unsubstituted C1-6 alkylene in which one or more carbon atoms may be optionally replaced by O, CO, NR2, NR2CO, CONR2, NR2SO2, SO2NR2, S and / or S (O) n； R1 is independently selected from H, substituted or unsubstituted C1-6 alkyl, substituted or unsubstituted C2-6 alkenyl, substituted or unsubstituted C2-6 alkynyl, substituted or unsubstituted C1-6 alkoxy, OH, halogen, CN, NO2 , NR2R3, SO2R3, SO2NR2R3, CF3, OCF3, NR2SO2R3, CO2R3, COSR3, CSR3, COR3, NR2, CSR3, NR2CSR3, CONR2R3, NR2COR3, NR2CONR2R3, SO3R3, C3-8 substituted or unsubstituted substituted or substituted cycloalkyl substituted or unsubstituted heterocyclyl having up to 3 heteroatoms selected from N, O, S and SO2； R is independently selected from substituted or unsubstituted C1-6 alkyl, substituted or unsubstituted C2-6 alkenyl, substituted or unsubstituted C2-6 alkynyl, substituted or unsubstituted C1-6 alkoxy, OH, halogen, CN, NO2, CO2R3 , CONR2R3, NR2COR3, SO3R3, C3-8 cycloalkyl, aryl and heterocyclyl having up to 3 heteroatoms selected from N, O, S and SO2, each of which may be substituted with up to 3 substituents independently selected from substituted C1-6 alkyl or unsubstituted, substituted or unsubstituted C2-6 alkenyl, substituted or unsubstituted C2-6 alkynyl, substituted or unsubstituted C1-6 alkoxy, OH, OCF3, halogen, CN, NO2, NR2R3, SO2R3, SO2NR2R3, NR2SO2R3, CO2R3 , COR3, NR2COR3, R2NHCO2R3, CONR2R3, NR2CONR2R3 and substituted or unsubstituted heterocyclyl having up to 3 heteroatoms selected from N, O, S and SO2； R2 and R3 are independently selected from H, substituted or unsubstituted C1-6 alkyl, substituted or unsubstituted C2-6 alkenyl, substituted or unsubstituted C2-6 alkynyl, substituted or unsubstituted C1-6 alkoxy, CN, C3- cycloalkyl 8 substituted or unsubstituted, substituted or unsubstituted aryl and substituted or unsubstituted heterocyclyl having up to 3 heteroa
