BOCK, MARK G.,CHIKKANNA, DINESH,MCCARTHY, CLIVE,MOEBITZ, HENRIK,PANDIT, CHETAN
申请号：
ES10771491
公开号：
ES2487628T3
申请日:
2010.11.02
申请国别(地区):
ES
年份:
2014
代理人:
摘要：
Compound of formula (IA) ** Formula ** in which X is -N (R6) -, where R6 is H or (C1-C6) alkyl； R1a and R1b are each independently selected from hydroxyl, cyano, nitro, (C1-C6) alkyl, (C2-C6) alkenyl, (C2-C6) alkynyl, (C1-C6) alkoxy, (C2-C6) alkenyloxy, (C2-C6) alkynyloxy, halogen, (C1-C6) alkyl -C (O) -, -C (O) OH, -C (O) -O-(C1-C6) alkyl, amino, (C1-) alkyl C6) -NH-, di ((C1-C6) alkyl) N-, (C1-C6) alkyl -NH-C (O) -, di ((C1-C6) alkyl) NC (O) -, alkyl ( C1-C6) -C (O) -NH-, (C1-C6) alkyl -C (O) -N ((C1-C6) alkyl),, (C1-C6) -SO2-NH- alkyl, alkyl ( C1-C6) -SO2-N ((C1-C6) alkyl) -, (C1-C6) alkyl -S-, (C1-C6) alkyl -S (O) -, (C1-C6) alkyl -SO2 -, NH2-SO2-, (C1-C6) alkyl -NH-SO2- and di ((C1-C6) alkyl) N-SO2-, where each of said moieties (C1-C6) alkyl, alkenyl (C2-) C6) and (C2-C6) alkynyl are optionally substituted with one or more substituents each independently selected from halogen, hydroxyl, (C1-C6) alkoxy, amino, (C1-C6) -NH- alkyl, di (C1 (alkyl) -C6)) N- or cyano； R2a is H or C1-6 alkyl； R2b is a chemical moiety selected from (C1-C6) alkyl, (C2-C6) alkenyl, (C2-C6) alkynyl, NR10R12, cycloalkyl, aryl, heterocycloalkyl or heteroaryl, wherein said chemical moiety is optionally substituted with one to three substituents each independently selected from halogen, cyano, hydroxyl, (C1-C6) alkoxy, (C2-C6) alkenyloxy, (C2-C6) alkynyloxy, (C1-C6) alkyl, (C1-C6) alkyl ) substituted with halo, amino, (C1-C6) alkyl -NH-, di ((C1-C6) alkyl) N-, HC (O) -NH-, (C1-C6) alkyl -C (O) - NH -, HC (O) -N-(C1-C6) alkyl) -, (C1-C6) alkyl -C (O) -N ((C1-C6) alkyl) -, monocyclic cycloalkyl or monocyclic heterocycloalkyl, wherein said cycloalkyl and said heterocycloalkyl are optionally substituted with one or two substituents each independently selected from halogen, cyano, hydroxyl, (C1-C6) alkoxy, (C2-C6) alkenyloxy, (C2-C6) alkyloxy, (C1-C6) alkyl S-, C1-6 haloalkyl, amino, (C1-C6) alkyl-NH-, di ((C1-C6) alkyl) N-, H C (O) -NH-, (C1-C6) alkyl -C (O) -NH-, HC (O) -N-(C1-C6) alkyl) - or (C
