SHERIDAN, Joseph M.,HEAL, Jonathan R.,HAMILTON, William D.O.,PIKE, Ian
申请号：
ES11804754
公开号：
ES2553610T3
申请日:
2011.12.14
申请国别(地区):
ES
年份:
2015
代理人:
摘要：
A pharmaceutical composition comprising a compound of formula (IB) or a pharmaceutically acceptable salt or solvate thereof: wherein "Het B" represents indolyl or indolizinyl； Z represents CO； R1b represents aryl, C3-8 cycloalkyl, monocyclic or bicyclic heterocyclyl or a monocyclic or bicyclic heteroaryl ring system, wherein R1b may be substituted by one or more (eg, 1, 2 or 3) R4b groups； R4b represents halogen, C1-6 alkyl, C1-6 alkenyl, C1-6 alkynyl, C3-8 cycloalkyl, C1-6 haloalkyl, hydroxyl, C1-6 alkoxy, -O-C1-6 alkenyl, C1-6 haloalkoxy groups, -COOH, -CO-C1-6 alkyl, -COO-C1-6 alkyl, -CONH2, -CH2-CONH2, -NH-C1-6 alkyl, -NH-C2-6 alkenyl, -NH-CO-C1-alkyl -6, -CO-NH-C1-6 alkyl, -O-CH2-CO-NH-C1-6 alkyl, -CH2- CH2-CO-NH-C1-6 alkyl, -S-C1-6 alkyl, - SO-C1-6 alkyl, -SO2-C1-6 alkyl, -SO2-NH2, -SO2-NH-C1-6 alkyl, -S-CH2- CO-C2-6 alkenyl, -SO2-OH, amino, cyano , NO2,>； = O, -CO-NH- (CH2) 2) -OMe, -NH-C3-8 cycloalkyl, -CH2-CO-NH C3-8 cycloalkyl, -CO-heterocyclyl, -CO-heteroaryl, - COO- (CH2) 2-heterocyclyl, -CH2-aryl, -OCH2-aryl, -OCH2- heteroaryl, -CH2-O-CO-aryl, -O-aryl, -NH-CO-aryl, -NH-CO- heteroaryl, -NH-CO-CH2-aryl, -NH-aryl, aryl or heteroaryl, wherein said R4b aryl, heterocyclyl or heteroaryl groups may be optionally substituted with one or more halogen groups, C1-6 alkyl, C1- alkoxy 6,>； = S or hydroxyl and wherein said C1-6 alkyl or C2-6 alkenyl groups of R4b may be optionally substituted with one or more hydroxyl, amino, cyano, C1-6 alkoxy, CONH2 or -COO-C1-6 alkyl groups； m represents 2； and R2b represents amino or -CONH2.Una composición farmacéutica que comprende un compuesto de fórmula (IB) o una sal farmacéuticamente aceptable o un solvato del mismo: en donde "Het B" representa indolilo o indolizinilo； Z representa CO； R1b representa arilo, cicloalquilo C3-8, heterociclilo monocíclico o bicíclico o un sistema de anillos de heteroarilo monocíclico o bicíclico, en donde R1b puede estar sustituido por uno o varios (p. ej., 1, 2 o 3) grupos R4b； R4b represent
