DR. INCE STUART,DRA. HGEBARTH ANDREA,DR. BRIEM HANS,DR. BMER ULF,DR. BRFACKER LARS,DR. SCOTT WILLIAM,DR. REHWINKEL HARTMUT,DR. POLITZ OLIVER,DR. NEUHAUS ROLAND
申请号：
ARP120101200
公开号：
AR087148A1
申请日:
2012.04.09
申请国别(地区):
AR
年份:
2014
代理人:
摘要：
Compound 1 for the treatment of diseases related to uncontrolled cell proliferation: a formula compound (1),R1 is hydrogen, hydrogen Xi, nr5r6, halogen, cyanogen, CO (nr8r9),C (o) or8, C (o) (C1-6 tar)NHC (o) (C1-6 tar)NHS (o) 2r11, NHC (o) nhr11, - S (o) n-alkyl C1-6, - S (o) 2nr5r6, or a group selected from C1-6, Alcoy C1-6, cyclo-7, arilo, heterosexual, (C1-6 tar) - arilo, (C1-6) - heterosexual, - or (cycloquilo c3-7),-O-arilo, O - (isopropene c3-7),-O-heteromorphic, O - (C1-6 tar) - heteromorphic, or - (C1-6 tar) - (isocyclohexane c3-7),-O - (C1-6 tar) - arilo, alquenilo c2-6, c12-6 tar reservoir, one or more of the following substitutes are selected to replace this group of substances in the same or different forms: hydroxyl, halogen, C1-6 tar, C1-4, alcox C1-6, n8r9, cyano-c (o) n8r9, - C (o) or10, - NHC (o) R11, - NHC (o) nhr11, - nhr2 (R11), Cycloquilo c3-7, heterocycle c3-7, arilo； R2 is hydrogen, hydroxi, nr5r6, halogen, cyanogen, CO (nr8r9),C (o) or8, C (o) (C1-6 tar)NHC (C1-6 tar),NHS (o) 2r11, NHC (o) nhr11, - S (o) n-alkyl C1-6, - S (o) 2nr5r6, or a group selected from C1-6, Alcoy C1-6, cyclo-7, arilo, heterosexual, (C1-6 tar) - arilo, (C1-6) - heterosexual, - or (cycloquilo c3-7),-O-arilo, O - (isopropene c3-7),-O-heteromorphic, O - (C1-6 tar) - heteromorphic, or - (C1-6 tar) - (isocyclohexane c3-7),-O - (C1-6 tar) - arilo, alquenilo c2-6, c12-6 tar reservoir, one or more of the following substitutes are selected to replace this group of substances in the same or different forms: hydroxyl, halogen, C1-6 tar, C1-4, alcox C1-6, n8r9, cyano-c (o) n8r9, - C (o) or10, - NHC (o) R11, - NHC (o) nhr11, - nhr2 (R11), Isocyclic cyanogen c3-7, arilo； R3 is hydrogen, hydroxi, nr5r6, halogen, cyanogen, CO (nr8r9),C (o) or8, C (o) (C1-6 tar)NHS (o) 2r11, NHC (o) nhr11, - S (o) n-tar C1-6, - S (o) 2nr5r6, or a group selected from C1-6, Alcoy C1-6, cyclo-7, arilo, heterosexual (C1-6) - arilo, (C1-6) - heterosexual (C1-6) - or - (cycloquilo c3-7),-O-arilo, O - (isopro
