Compounds are provided that act as potent antagonists of theCCR2 receptor. The compounds are generally aryl sulfonamide derivativesand are useful in pharmaceutical compositions, methods for the treatment ofCCR2- mediated diseases and as controls in assays for the identification ofCCR2 antagonists. A compound of the formula (I) or a salt thereof: where:R1 and R2 are each independently hydrogen, halogen, C1-8alkyl, -CN. or C1-8R3 is independently hydrogen； R4 is hydrogen； R5 is halogen or C1-8 alkyl； R6is hydrogen； X1 is CR7, N or NO； X2 and X4 are N or NO； X3 is CR7； X6 and X7are each independently selected from CR7, N, and NO； each R7 is independentlyhaloalkyl, provided that at least one of R1 1 or R2 is other than hydrogen；eachselected from the group consisting of hydrogen, halogen, substituted orunsubstituted C2-8 alkyl, substituted or unsubstitued C2-8 alke.pi.yl,substituted or-C(O)NR0R8, -OC(O)NR9R8 , -NR10C(O)R8, -NR10C(O)NR9R8, -NR9R8,-NR10CO2R8, -SR8, -S(O)R8, -S(O)2R8, -S(O)2NR9R8, -N10S(O)2R8, substitutedor unsubstituted C6-10 aryl, substituted or unsubstituted 5- to 10-memberedheteroaryl and substituted or unsubstituted 3- to 10-membered heterocyclyl；unsubstituted C2-8 alkynyl, -CN. =O, -NO2, -OR6, -OC(O)R8, -CO2R8, -C(O)R8,
