BURCH, Jason,GOLDSMITH, Richard A.,ORTWINE, Daniel Fred,PASTOR, Richard,PEI, Zhonghua
申请号：
ES12750354
公开号：
ES2573336T3
申请日:
2012.08.10
申请国别(地区):
ES
年份:
2016
代理人:
摘要：
A compound of formula I: ** Formula ** stereoisomers or a pharmaceutically acceptable salt thereof, wherein: X, X1, X2 are C and X3 is C or N； R1, R2, R3 and R4 independently do not exist, they are hydrogen, C1-C12 alkyl, C2-C12 alkenyl, C2-C12 alkynyl, halogen, -CN, -OR7, -SR7, -NR7R8, -CF3, -OCF3, - NO2, -C (O) R7, -C (O) OR7, -C (O) NR7R8, -NR7C (O) R8, -S (O) 1-2R7, - NR7S (O) 1-2R, -S (O) 1-2NR7R8, C3-C6 cycloalkyl, 3-10 membered heterocyclyl or 6-10 membered aryl, in which R1, R2, R3 and R4 are independently optionally substituted with R9； R5 independently does not exist, it is C1-C6 alkylene, C2-C6 alkenylene, C2-C6 alkynylene, wherein said alkylene, alkenylene and alkynylene are independently optionally substituted with halogen, oxo, C1-C12 alkyl, C2-C12 alkenyl, alkynyl C2-C12, -OR16, -SR16, -NR16R17, -CN, -C (O) R16, -C (O) OR16, -NR16C (O) R17, - NR16S (O) 1-2R17, -CF3, - OCF3, 3-10 membered heterocyclyl or 6-10 membered aryl, and wherein said alkyl, alkenyl, alkynyl, heterocyclyl and phenyl are independently optionally substituted with R9； R6 is hydrogen, C3-C10 cycloalkyl, 3-10 membered heterocyclyl or 6-10 membered aryl, wherein R6 is independently optionally substituted with R9； each R7 and R8 are independently hydrogen, C1-C6 alkyl, C3-C6 cycloalkyl, 3- and 6-membered heterocyclyl or phenyl, wherein said alkyl, cycloalkyl, heterocyclyl and phenyl are independently optionally substituted with halogen, -CN, - CF3, -OCF3, oxo or C1-C6 alkyl optionally substituted with halogen or oxo； or R7 and R8 are independently taken together with the atom to which they are attached to form a 3- to 6-membered heterocyclyl optionally substituted by halogen, oxo or C1-C6 alkyl optionally substituted by halogen or oxo； each R9 is independently hydrogen, oxo, C1-C12 alkyl, C2-C12 alkenyl, C1-C12 alkynyl, halogen, - (C0-C6 alkylene) CN, - (C0-C6 alkylene) OR10, - (C0-C6 alkylene) SR10, - (C0-C6 alkylene) NR10R11, - (C0-C6 alkylene) CF3, - (C0-C6 alkylene) NO2, - (C0-C6 al
