The present invention relates to a heteroaryl fused [4,3-c]pyrimidin-5-amine derivative, a preparation method and a pharmaceutical use thereof. In particular, the present invention relates to a heteroaryl fused [4,3-c]pyrimidin-5-amine derivative as shown by general formula (I), the preparation method thereof and a pharmaceutical composition containing same, and the use thereof as a therapeutic agent. Particularly the use as an A2a receptor antagonist, and the use in the preparation of a medicament for treating disease or condition by inhibiting A2a receptor. The definition of each substituent of the general formula (I) is the same as that in the description.本發明涉及雜芳基并[4,3-c]嘧啶-5-胺類衍生物、其製備方法及其在醫藥上的使用。具體而言，本發明涉及一種通式(I)所示的雜芳基并[4,3-c]嘧啶-5-胺類衍生物、其製備方法及含有該衍生物的醫藥組成物以及其作為治療劑，特別是作為A2a受體拮抗劑的用途和在製備用於治療藉由對A2a受體的抑制而改善的病況或病症的藥物中的用途，其中通式(I)的各取代基與說明書中的定義相同。
