The present invention relates to phenyl acrylic amide derivatives, preparation process thereof and pharmaceutical use thereof. In particular, the present invention relates to phenyl acrylic amide derivatives as shown in the formula (I), a preparation method thereof and a pharmaceutical composition containing the same, for use as a kappa opioid receptor (KOR receptor) agonist and for use in the prevention and / or treatment of diseases such as pain and pain related diseases, wherein each substitute of general formula (I) is defined as the specification.本發明涉及苯基丙醯胺類衍生物、其製備方法及其在醫藥上的應用。特别地，本發明涉及通式(I)所示的苯基丙醯胺類衍生物、其製備方法及含有該衍生物的醫藥組成物，以及其作為κ鴉片類物質受體(KOR受體)激動劑的用途，和其在製備治療和/或預防疼痛和疼痛相關疾病的藥物中的用途。其中通式(I)的各取代基與說明書中的定義相同。
