The present invention relates to amide derivatives and salts thereof, preparation processes and pharmaceutical use thereof. Specifically, the present invention relates to amide derivatives of general formula (I) and the pharmaceutical composition, as well as their use as a therapeutic agent, especially these compounds are inhibitors of the microsomal prostaglandin E synthase-1 (mPGES-1) and are therefore useful in the treatment of pain and/or inflammation from a variety of diseases or conditions, wherein each substitute of general formula (I) is defined as the specification.本發明涉及醯胺類衍生物及其可藥用鹽、其製備方法及其在醫藥上的應用。具體而言，本發明涉及一種通式(I)所示醯胺類衍生物、其製備方法及含有該衍生物的醫藥組成物，以及其作為治療劑，特別是作為微粒體前列腺素E合成酶-1(mPGES-1)抑制劑的用途和其在製備治療和/或預防炎症和/或疼痛等疾病或病症的藥物中的用途，其中通式(I)中的各取代基的定義與說明書中的定義相同。
