The present invention relates to oxaspirocycle derivatives, a preparation method thereof and pharmaceutical use thereof. Particularly, the present invention relates to oxaspirocycle derivatives represented by general formula (I), a preparation method thereof and pharmaceutical compositions containing the derivatives, which can be used as a MOR receptor agonist and used for preparation of drugs for the treatment and/or prevention of pain and pain related disorders. The definition of each substituent group in general formula (I) is the same as the definition in the description.本發明涉及氧雜螺環類衍生物、其製備方法及其在醫藥上的應用。特別地，本發明涉及通式(I)所示的氧雜螺環類衍生物、其製備方法及含有該衍生物的藥物組成物，以及其作為MOR受體促效劑的用途，和其在製備治療和/或預防疼痛和疼痛相關疾病的藥物中的用途。其中通式(I)的各取代基同說明書中的定義相同。
