The present invention relates to 3,4-dipyridinyl pyrazole derivatives, a preparation method thereof and pharmaceutical use thereof. Specifically, The present invention relates to 3,4-dipyridinyl pyrazole derivatives represented by general formula (I), a preparation method thereof, pharmaceutical compositions containing the derivatives and use of treatment diseases. Particularly, the use of a TGF-β inhibitor and the use in the manufacture of a medicament for treating, preventing or reducing cancer mediated by over expression of TGF-β. The definition of each substituent group in general formula (I) is the same as the definition in the description.本發明涉及3,4-二吡啶基吡唑類衍生物、其製備方法及其在醫藥上的應用。具體而言，本發明涉及一種通式(I)所示的新的3,4-二吡啶基吡唑類衍生物、其製備方法及含有該衍生物的醫藥組成物及其作為治療劑，特別是作為TGF-β抑制劑的用途和在製備治療、預防或減少由TGF-β過度表達介導的癌症的藥物中的用途，其中通式(I)的各取代基與說明書中的定義相同。
