SHANGHAI HENGRUI PHARMACEUTICAL CO., LTD.;JIANGSU HENGRUI MEDICINE CO., LTD.
发明人:
LI, XIN,李心,DONG, QING,董庆,董慶,SUN, PIAOYANG,孙飘扬,孫飄揚
申请号：
TW104140503
公开号：
TW201620898A
申请日:
2015.12.03
申请国别(地区):
TW
年份:
2016
代理人:
摘要：
The present invention relates to pyridinecarboxamides derivatives, preparation processes and pharmaceutical use thereof. Specifically, the present invention relates to pyridinecarboxamides derivatives of general formula (I) and the pharmaceutical composition, as well as their use as a therapeutic agent, especially these compounds are inhibitors of ROMK and are therefore useful in the treatment and/or prevention of hypertension and heart failure, wherein each substitute of general formula (I) is defined as the specification.本發明涉及吡啶甲醯胺類衍生物、其製備方法及其在醫藥上的應用。具體而言，本發明涉及一種通式(I)所示吡啶甲醯胺類衍生物、其製備方法及含有該衍生物的藥物組成物，以及其作為治療劑，特別是作為腎外髓質分泌鉀通道(ROMK)抑制劑的用途和其在製備治療和/或預防高血壓和心臟衰竭的藥物中的用途，其中通式(I)中的各取代基的定義與說明書中的定義相同。
