JIANGSU HANSOH PHARMACEUTICAL GROUP CO., LTD.;SHANGHAI HANSOH BIOMEDICAL CO., LTD
发明人:
SU, YIDONG,苏熠东,蘇熠東,GU, PENG,古鹏,古鵬,CHEN, XIAOPO,陈晓坡,陳曉坡,LIU, LEI,刘磊,劉磊,BAO, RUDI,包如迪
申请号：
TW107101150
公开号：
TW201825490A
申请日:
2018.01.11
申请国别(地区):
TW
年份:
2018
代理人:
摘要：
The present invention relates to pyrrolo[2,3-c]pyridine derivatives, preparation methods and pharmaceutical uses thereof. Specifically, the invention relates to pyrrolo[2,3-c] pyridine derivatives represented by general formula(I), their preparation methods and pharmaceutical compositions, and their applications as BRD4 inhibitors in the preparation of drugs. The drugs can treat diseases related to cancer, inflammation, chronic hepatopathy, diabetes, cardiovascular or AIDS. Each substituent in the general formula(I)is defined as that in the specification.本發明涉及吡咯並[2,3-c]吡啶類衍生物、其製備方法及其在醫藥上的應用。特別地，本發明涉及通式(I)所示的吡咯並[2,3-c]吡啶類衍生物、其製備方法及含有該衍生物的醫藥組成物，及其作為BRD4抑制劑在治療癌症、炎症、慢性肝病、糖尿病、心血管疾病和AIDS等相關疾病的用途，其中通式(I)中的各取代基與說明書中的定義相同。
