The present invention relates to thiophene-cycloalkyl or thiophene-heterocyclic derivatives, preparation processes and pharmaceutical use thereof. Specifically, the present invention relates to thiophene-cycloalkyl or thiophene-heterocyclic derivatives of general formula (I) and the pharmaceutical composition, as well as their use as a therapeutic agent, especially these compounds are inhibitors of Npt2b and are therefore useful in the treatment and/or prevention of hyperphosphatemia, wherein each substitute of general formula (I) is defined as the specification.本發明涉及噻吩並環烷基或噻吩並雜環基類衍生物、其製備方法及其在醫藥上的應用。具體而言,本發明涉及一種通式(I)所示噻吩並環烷基或噻吩並雜環基類衍生物、其製備方法及含有該衍生物的醫藥組成物,以及其作為治療劑,特別是作為腸2B型磷酸鈉協同轉運蛋白(Npt2b)抑制劑的用途和其在製備治療和/或預防高磷血症的藥物中的用途,其中通式(I)中的各取代基的定義與說明書中的定義相同。
