The present invention relates to a 1,2,4-triazin-3-amine derivative, a preparation method and a pharmaceutical use thereof. In particular, the present invention relates to a 1,2,4-triazin-3-amine derivative as shown by general formula(I), the preparation method thereof and a pharmaceutical composition containing same, and the use thereof as a therapeutic agent. Particularly the use as an A2a receptor antagonist, and the use in the preparation of a medicament for treating disease or condition by inhibiting A2a receptor. The definition of each substituent of the general formula(I)is the same as that in the description.本發明涉及1,2,4-三嗪-3-胺類衍生物、其製備方法及其在醫藥上的應用。具體而言，本發明涉及一種通式(I)所示的1,2,4-三嗪-3-胺類衍生物、其製備方法及含有該衍生物的醫藥組成物以及其作為治療劑，特別是作為A2a受體拮抗劑的用途和在製備用於治療通過對A2a受體的抑制而改善的病況或病症的藥物中的用途，其中通式(I)的各取代基與說明書中的定義相同。
