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Apoptosis inducing agents for the treatment of cancer and immune and autoimmune diseases
- 专利权人:
- AbbVie Inc.
- 发明人:
- TAO, Zhi-Fu,WANG, Xilu,WENDT, Michael D.,SOUERS, Andrew J.,JUDD, Andrew S.,KUNZER, Aaron,SULLIVAN, Gerard
- 申请号：
- ES14709488
- 公开号：
- ES2689679T3
- 申请日:
- 2014.02.21
- 申请国别(地区):
- ES
- 年份:
- 2018
- 代理人:
- 摘要：
- A compound chosen from the group consisting of: 4- (4 - {[2- (4-chlorophenyl) -4,4-dimethylcyclohex-1-en-1-yl] methyl} piperazin-1-yl) -N- [ (4 - {[(2R) -1,4-dioxan-2- ylmethyl] amino} -3-nitrophenyl) sulfonyl] -2- (1 H -pyrrolo [2,3-b] pyridin-5-yloxy) benzamide； 4- (4 - {[2- (4-chlorophenyl) -4,4-dimethylcyclohex-1-en-1-yl] methyl} piperazin-1-yl) -N - [(3-nitro-4 - {[ (5R, 8R) -1-oxaspiro [4,5] dec-8-ylmethyl] amino} phenyl) sulfonyl] -2- (1 H -pyrrolo [2,3-b] pyridin-5-yloxy) benzamide； 4- (4 - {[2- (4-chlorophenyl) -4,4-dimethylcyclohex-1-en-1-yl] methyl} piperazin-1-yl) -N - [(4 - {[(4-hydroxytetrahydro -2H-pyran-4- yl) methyl] amino} -3-nitrophenyl) sulfonyl] -2- (1H-pyrrolo [2,3-b] pyridin-5-yloxy) benzamide； 4- (4 - {[2- (4-chlorophenyl) -4,4-dimethylcyclohex-1-en-1-yl] methyl} piperazin-1-yl) -N - ({4 - [(1,4- dioxaspiro [4,5] dec-8-ylmethyl) amino] -3-nitrophenyl} sulfonyl) -2- (1 H -pyrrolo [2,3-b] pyridin-5-yloxy) benzamide； 4- (4 - {[2- (4-chlorophenyl) -4,4-dimethylcyclohex-1-en-1-yl] methyl} piperazin-1-yl) -N - [(4 - {[(2S) - 1,4-dioxan-2- ylmethyl] amino} -3-nitrophenyl) sulfonyl] -2- (1 H -pyrrolo [2,3-b] pyridin-5-yloxy) benzamide； 4- (4 - {[2- (4-chlorophenyl) -4,4-dimethylcyclohex-1-en-1-yl] methyl} piperazin-1-yl) -N - {[4 - ({[4- ( hydroxymethyl) tetrahydro-2Hpiran-4-yl] methyl} amino) -3-nitrophenyl] sulfonyl} -2- (1 H -pyrrolo [2,3-b] pyridin-5-yloxy) benzamide； 4- (4 - {[2- (4-chlorophenyl) -4,4-dimethylcyclohex-1-en-1-yl] methyl} piperazin-1-yl) -N - [(4 - {[(3-hydroxyoxetan -3-yl) methyl] amino} -3-nitrophenyl) sulfonyl] -2- (1 H -pyrrolo [2,3-b] pyridin-5-yloxy) benzamide； 4- (4 - {[2- (4-chlorophenyl) -4,4-dimethylcyclohex-1-en-1-yl] methyl} piperazin-1-yl) -N - {[4 - ({[(2S, 5R) -5-methyl-1,4-dioxan-2- yl] methyl} amino) -3-nitrophenyl] sulfonyl} -2- (1 H -pyrrolo [2,3-b] pyridin-5-yloxy) benzamide； 4- (4 - {[2- (4-chlorophenyl) -4,4-dimethylcyclohex-1-en-1-yl] methyl} piperazin-1-yl) -N - [(4 - {[(4-cyanotetrahydro -2H-pyran-4- yl) m
- 来源网站：
- 中国工程科技知识中心
- 来源网址：
- http://www.ckcest.cn/home/
