APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES

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专利权人:

ABBOTT LABORATORIES

发明人:

BRUNCKO, MILAN,DAI, YUJIA,DOHERTY, GEORGE, A,ELMORE, STEVEN, W,HASVOLD, LISA,HEXAMER, LAURA,KUNZER, AARON, R,MANTEI, ROBERT, A,MCCLELLAN, WILLIAM, J,PARK, CHANG, H

申请号：

NZ59280209

公开号：

NZ592802A

申请日:

2009.12.04

申请国别(地区):

NZ

年份:

2013

代理人:

摘要：

592802 Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein. Compounds of the present disclosure include: 2-[(6-amino-5-chloropyridin-3-yl)oxy]-4-(4-{ [2-(4-chlorophenyl)-4,4-dimethylcyclohex-l-en-l-yl]methyl} piperazin-l-yl)-N-({ 3-nitro-4-[(tetrahydro-2H-pyran-4-ylmethyl)amino]phenyl} sulfonyl)benzamide, N-({ 5-chloro-6-[(4,4-difluorocyclohexyl)methoxy]pyridin-3-yl} sulfonyl)-4-(4-{ [4-(4-chlorophenyl)-6,6-dimethyl-5,6-dihydro-2H-pyran-3-yl]methyl} piperazin-1-yl)-2-[(6-fluoro-1H-indol-5-yl)oxy]benzamide, 4-(4-{ [2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-5 yl]methyl} piperazin-1-yl)-N-({ 3-nitro-4-[(tetrahydro-2H-pyran-4-ylmethyl)amino]phenyl} sulfonyl)-2-[2-(1H-pyrazol-4-yl)phenoxy]benzamide, Trans-2-[(6-amino-5-chloropyridin-3-yl)oxy]-4-(4-{ [2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl} piperazin-1-yl)-N-[(4-{ [(4-cyanocyclohexyl)methyl]amino} -3-nitrophenyl)sulfonyl]benzamide, 2-[(2-amino-5-bromopyridin-4-yl)oxy]-4-(4-{ [2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl} piperazin-1-yl)-N-({ 3-nitro-4-[(tetrahydro-2H-pyran-4-ylmethyl)amino]phenyl} sulfonyl)benzamide, N-({ 5-chloro-6-[(4-fluorotetrahydro-2H-pyran-4-yl)methoxy]pyridin-3-yl} sulfonyl)-4-(4-{ [2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl} piperazin-1-yl)-2-[(6-fluoro-1H-indol-5-yl)oxy]benzamide, tert-butyl 4-(5-(4-{ [2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl} piperazin-1-yl)-2-{ [({ 3-nitro-4-[(tetrahydro-2H-pyran-4-ylmethyl)amino]phenyl} sulfonyl)amino]carbonyl} phenoxy)pyridin-2-ylcarbamate and 2-(4-(acetylamino)phenoxy)-4-(4-((4'-chloro-1,1'-biphenyl-2-yl)methyl)piperazin-1-yl)-N-((3-nitro-4-((tetrahydro-2H-pyran-4-ylmethyl)amino)phenyl)sulfonyl)benzamide.

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