Apoptosis inducing agents for the treatment of cancer and immune and autoimmune diseases

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专利权人:

AbbVie Inc.;The Walter and Eliza Hall Institute of Medical Research

发明人:

BRUNCKO, Milan,DAI, Yujia,DING, Hong,DOHERTY, George,ELMORE, Steven,HASVOLD, Lisa,HEXAMER, Laura,KUNZER, Aaron,MANTEI, Robert,MCCLELLAN, William,PARK, Chang,PARK, Cheol-Min,PETROS, Andrew,SONG, Xiaoho

申请号：

ES09768289

公开号：

ES2622344T3

申请日:

2009.12.04

申请国别(地区):

ES

年份:

2017

代理人:

摘要：

A compound or one of its therapeutically acceptable salts, wherein the compound is selected from the group consisting of: 4- (4 - {[2- (4-chlorophenyl) -4,4-dimethylcyclohex-1-en-1-yl ] methyl} piperazin-1-yl) -2- (3-fluorophenoxy) -N - ({4 - [(3-morpholin-4-ylpropyl) amino] -3-nitrophenyl} sulfonyl) benzamide； 4- (4 - {[2- (4-chlorophenyl) -4,4-dimethylcyclohex-1-en-1-yl] methyl} piperazin-1-yl) -2- (2-fluorophenoxy) -N - ({ 4 - [(3-morpholin-4-ylpropyl) amino] -3-nitrophenyl} sulfonyl) benzamide； 4- (4 - {[2- (4-chlorophenyl) -4,4-dimethylcyclohex-1-en-1-yl] methyl} piperazin-1-10 yl) -2- (2-fluorophenoxy) -N- ( {4 - [(2-morpholin-4-ylethyl) amino] -3-nitrophenyl} sulfonyl) benzamide； 4- (4 - {[2- (4-chlorophenyl) -4,4-dimethylcyclohex-1-en-1-yl] methyl} piperazin-1-yl) -2- (3-fluorophenoxy) -N - ({ 4 - [(2-morpholin-4-ylethyl) amino] -3-nitrophenyl} sulfonyl) benzamide； 4- (4 - {[2- (4-chlorophenyl) -4,4-dimethylcyclohex-1-en-1-yl] methyl} piperazin-1-yl) -2- (2,3-difluorophenoxy) -N- ({4 - [(2-morpholin-4-ylethyl) amino] -3-nitrophenyl} sulfonyl) benzamide； 4- (4 - {[2- (4-chlorophenyl) -4,4-dimethylcyclohex-1-en-1-yl] methyl} piperazin-1-yl) -N - [(4 - {[3- (dimethylamino) ) propyl] amino} -3-nitrophenyl) sulfonyl] -2- (2-fluorophenoxy) benzamide； 2- (3-chlorophenoxy) -4- (4 - {[2- (4-chlorophenyl) -4,4-dimethylcyclohex-1-en-1-yl] methyl} piperazin-1-yl) -N - ({ 3-nitro-4- [(tetrahydro-2H-pyran-4-ylmethyl) amino] phenyl} sulfonyl) benzamide； 2- (4-amino-3-chlorophenoxy) -4- (4 - {[2- (4-chlorophenyl) -4,4-dimethylcyclohex-1-en-1-yl] methyl} piperazin-1-yl) - N - ({3-nitro-4- [(tetrahydro-2H-pyran-4-ylmethyl) amino] phenyl} sulfonyl) benzamide； 2- (2-Chlorophenoxy) -4- (4 - {[2- (4-chlorophenyl) -4,4-dimethylcyclohex-1-en-1-yl] methyl} piperazin-1-yl) -N - [( 3-nitro-4 - {[3- (3- oxopiperazin-1-yl) propyl] amino} phenyl) sulfonyl] benzamide； 2- (3-amino-5-chlorophenoxy) -4- (4 - {[2- (4-chlorophenyl) -4,4-dimethylcyclohex-1-en-1-yl] methyl} piperazin-1-yl) - N -

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